Shaffer JF*, Gupta A*, Kharkwal G, Linares EE, Holmes AD, Julian Swartz, Katzman S, and Sharma U. Epididymis-specific RNase A family genes regulate fertility and small RNA processing. Journal of Biological Chemistry,
, , ,A sperm-enriched 5’fragment of tRNA-Valine regulates preimplantation embryonic transcriptome and development. BioRxiv August 2024
, Sperm RNA Payload: Implications for Intergenerational Epigenetic Inheritance. International Journal of Molecular Sciences. March 2023.
Rinaldi V*, Donnard D*, Gellatly K, Rasmussen M, Kucukural A, Yukselen O, Garber M, Sharma U, and Rando O. An atlas of cell types in the mammalian epididymis and vas deferens. eLife 2020;9:e55474 July 2020.
Sharma U. Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information. Front. Cell Dev. Biol., 09 October 2019
Sharma U, Sun F, Conine C, Reichholf B, Kukreja S, Herzog VA, Ameres SL, and Rando OJ. Small RNAs are trafficked from the epididymis to developing mammalian sperm. Developmental Cell 46, 481–494 (2018)
Related news articles and previous publications:
Dads Pass On More Than Genetics in Their Sperm
Changes to sperm’s small RNA in the epididymis may help ensure mouse embryos implant.
Changes to small RNA in sperm may help fertilization.
Ichikawa Y*, Connelly CF*, Appleboim A*, Jacobi H, Abshiru NA, Chou HJ, ChenY, Sharma U, Zheng Z, Thomas PM, Bajaj V, Kelleher NL, Friedman N, Bolon DN, Rando OJ † and Kaufman PD †. A synthetic biology approach to probing nucleosome symmetry. Elife. 2017 10.7554/eLife.28836
Sharma U and Rando OJ. Metabolic inputs into the epigenome. Cell Metabolism 25(3):544-558 (2017)
Sharma U*, Conine CC*, Shea JM, Boskovic A, Derr AG, Bing XY, Belleannee C, Kucukural A, Serra RW, Sun F, Carone BR, Ricci EP, Li XZ, Fauquier L, Moore MJ, Sullivan R, Mello CC, Garber M, and Rando OJ; Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science. 2016 Jan 22; 351(6271): 391–396.
Are you inheriting more than genes from your father?
A father’s diet affects the RNA of his sperm, mouse study shows
Sharma U and Rando OJ; Father-Son Chats: Inheriting Stress through Sperm RNA. Cell Metabolism 19: 894-895 (2014)
Sharma U, Stefanova D, and Holmes SG; Histone variant H2A.Z functions in sister chromatid cohesion in Saccharomyces cerevisiae. 2012 Cell. Biol. 33: 3473-3481 (2012)
Martins-Taylor K*, Sharma U*, Tania Rozario, and Holmes SG. H2A.Z (Htz1) controls the cell-cycle dependent establishment of transcriptional silencing at Saccharomyces cerevisiae. Genetics 187:89-104 (2011)
Please follow this link to find the lab’s publications in the National Library of Medicine’s PubMed database.